| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 beta |
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| Ligand | BDBM50355789 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_776544 (CHEMBL1913641) |
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| IC50 | 2700±n/a nM |
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| Citation |  Stierle, DB; Stierle, AA; Patacini, B; McIntyre, K; Girtsman, T; Bolstad, E Berkeleyones and related meroterpenes from a deep water acid mine waste fungus that inhibit the production of interleukin 1-ß from induced inflammasomes. J Nat Prod74:2273-7 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 beta |
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| Name: | Interleukin-1 beta |
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| Synonyms: | IL1B | IL1B_HUMAN | IL1F2 | Interleukin 1-beta | Interleukin-1 beta | hIL-1beta |
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| Type: | Cytokine |
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| Mol. Mass.: | 30734.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01584 |
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| Residue: | 269 |
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| Sequence: | MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG
FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR
SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE
KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST
SQAENMPVFLGGTKGGQDITDFTMQFVSS
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| BDBM50355789 |
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| n/a |
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| Name | BDBM50355789 |
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| Synonyms: | CHEMBL1911627 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H38O6 |
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| Mol. Mass. | 446.5763 |
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| SMILES | COC(=O)[C@@]12C(=C)[C@@](C)(C[C@H]3[C@]4(C)CC[C@@H](O)C(C)(C)[C@H]4CC[C@]13C)C(=O)[C@](C)(O)C2=O |r,THB:6:5:10.23.9:25.30.27| |
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| Structure | 
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