| Reaction Details |
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 | Report a problem with these data |
| Target | Type 1 fimbrin D-mannose specific adhesin |
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| Ligand | BDBM50357418 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_788106 (CHEMBL1919133) |
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| IC50 | 144±n/a nM |
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| Citation |  Schwardt, O; Rabbani, S; Hartmann, M; Abgottspon, D; Wittwer, M; Kleeb, S; Zalewski, A; Smieško, M; Cutting, B; Ernst, B Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists. Bioorg Med Chem19:6454-73 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type 1 fimbrin D-mannose specific adhesin |
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| Name: | Type 1 fimbrin D-mannose specific adhesin |
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| Synonyms: | Adhesin protein fimH | FIMH_ECOLI | fimH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31474.61 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | ChEMBL_1298296 |
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| Residue: | 300 |
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| Sequence: | MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLS
TQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRT
DKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTG
GCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQ
GVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ
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| BDBM50357418 |
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| n/a |
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| Name | BDBM50357418 |
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| Synonyms: | CHEMBL1917479 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16F3N3O5 |
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| Mol. Mass. | 375.2998 |
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| SMILES | OC[C@H]1O[C@@H]([C@@H](O)[C@@H](O)[C@@H]1O)n1cc(nn1)-c1ccc(cc1)C(F)(F)F |r| |
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| Structure | 
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