| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-7 |
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| Ligand | BDBM50358023 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_786495 (CHEMBL1921076) |
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| Ki | 91.40±n/a nM |
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| Citation |  Dallanoce, C; Frigerio, F; Grazioso, G; Matera, C; Visconti, GL; De Amici, M; Pucci, L; Pistillo, F; Fucile, S; Gotti, C; Clementi, F; De Micheli, C New spirocyclic¿²-isoxazoline derivatives related to selective agonists ofa7 neuronal nicotinic acetylcholine receptors. Eur J Med Chem46:5790-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-7 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-7 |
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| Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56502.44 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q05941 |
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| Residue: | 502 |
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| Sequence: | MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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| BDBM50358023 |
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| n/a |
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| Name | BDBM50358023 |
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| Synonyms: | CHEMBL1917550 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H19N2O2 |
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| Mol. Mass. | 211.2802 |
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| SMILES | COC1=NOC2(C1)C[N+]1(C)CCC2CC1 |t:2,(12.27,-6.73,;11.95,-8.24,;10.49,-8.71,;9.24,-7.8,;7.99,-8.71,;8.47,-10.17,;10.01,-10.17,;8.47,-11.71,;7.14,-12.48,;7.12,-14.02,;5.81,-11.71,;5.81,-10.17,;7.14,-9.4,;6.35,-10.73,;7.89,-11.14,)| |
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| Structure | 
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