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TargetLiver carboxylesterase
LigandBDBM50358312
Substrate/Competitorn/a
Meas. Tech.ChEMBL_791004 (CHEMBL1925665)
IC50 6060±n/a nM
Citation Sokolova, NVNenajdenko, VGSokolov, VBSerebryakova, OGMakhaeva, GF Synthesis and testing of trifluoromethyl-containing phosphonate-peptide conjugates as inhibitors of serine hydrolases. Bioorg Med Chem Lett21:7216-8 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Liver carboxylesterase
Name:Liver carboxylesterase
Synonyms:Carboxylesterase | EST1_PIG
Type:PROTEIN
Mol. Mass.:62009.98
Organism:Sus scrofa
Description:ChEMBL_427761
Residue:566
Sequence:
MWLLPLVLTSLASSATWAGQPASPPVVDTAQGRVLGKYVSLEGLAQPVAVFLGVPFAKPP
LGSLRFAPPQPAEPWSFVKNTTSYPPMCCQDPVVEQMTSDLFTNGKERLTLEFSEDCLYL
NIYTPADLTKRGRLPVMVWIHGGGLVLGGAPMYDGVVLAAHENVVVVAIQYRLGIWGFFS
TGDEHSRGNWGHLDQVAALHWVQENIANFGGDPGSVTIFGESAGGESVSVLVLSPLAKNL
FHRAISESGVALTVALVRKDMKAAAKQIAVLAGCKTTTSAVFVHCLRQKSEDELLDLTLK
MKFLTLDFHGDQRESHPFLPTVVDGVLLPKMPEEILAEKDFNTVPYIVGINKQEFGWLLP
TMMGFPLSEGKLDQKTATSLLWKSYPIANIPEELTPVATDKYLGGTDDPVKKKDLFLDLM
GDVVFGVPSVTVARQHRDAGAPTYMYEFQYRPSFSSDKKPKTVIGDHGDEIFSVFGFPLL
KGDAPEEEVSLSKTVMKFWANFARSGNPNGEGLPHWPMYDQEEGYLQIGVNTQAAKRLKG
EEVAFWNDLLSKEAAKKPPKIKHAEL
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BDBM50358312
n/a
NameBDBM50358312
Synonyms:CHEMBL1922541
TypeSmall organic molecule
Emp. Form.C8H10F3O5P
Mol. Mass.274.131
SMILESCOC(=O)C(OP(C)(=O)OCC#C)C(F)(F)F
Structure
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