| Reaction Details |
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 | Report a problem with these data |
| Target | Liver carboxylesterase |
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| Ligand | BDBM50358317 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_791004 (CHEMBL1925665) |
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| IC50 | 182000±n/a nM |
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| Citation |  Sokolova, NV; Nenajdenko, VG; Sokolov, VB; Serebryakova, OG; Makhaeva, GF Synthesis and testing of trifluoromethyl-containing phosphonate-peptide conjugates as inhibitors of serine hydrolases. Bioorg Med Chem Lett21:7216-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Liver carboxylesterase |
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| Name: | Liver carboxylesterase |
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| Synonyms: | Carboxylesterase | EST1_PIG |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62009.98 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_427761 |
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| Residue: | 566 |
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| Sequence: | MWLLPLVLTSLASSATWAGQPASPPVVDTAQGRVLGKYVSLEGLAQPVAVFLGVPFAKPP
LGSLRFAPPQPAEPWSFVKNTTSYPPMCCQDPVVEQMTSDLFTNGKERLTLEFSEDCLYL
NIYTPADLTKRGRLPVMVWIHGGGLVLGGAPMYDGVVLAAHENVVVVAIQYRLGIWGFFS
TGDEHSRGNWGHLDQVAALHWVQENIANFGGDPGSVTIFGESAGGESVSVLVLSPLAKNL
FHRAISESGVALTVALVRKDMKAAAKQIAVLAGCKTTTSAVFVHCLRQKSEDELLDLTLK
MKFLTLDFHGDQRESHPFLPTVVDGVLLPKMPEEILAEKDFNTVPYIVGINKQEFGWLLP
TMMGFPLSEGKLDQKTATSLLWKSYPIANIPEELTPVATDKYLGGTDDPVKKKDLFLDLM
GDVVFGVPSVTVARQHRDAGAPTYMYEFQYRPSFSSDKKPKTVIGDHGDEIFSVFGFPLL
KGDAPEEEVSLSKTVMKFWANFARSGNPNGEGLPHWPMYDQEEGYLQIGVNTQAAKRLKG
EEVAFWNDLLSKEAAKKPPKIKHAEL
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| BDBM50358317 |
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| n/a |
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| Name | BDBM50358317 |
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| Synonyms: | CHEMBL1922546 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23F9N5O5P |
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| Mol. Mass. | 627.3972 |
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| SMILES | C[C@@H](Cn1cc(COP(C)(=O)OC(C(F)(F)F)C(F)(F)F)nn1)NC(=O)CN(Cc1ccccc1)C(=O)C(F)(F)F |r| |
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| Structure | 
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