Ki Summary

Reaction Details

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Target

Glutamate carboxypeptidase 2

Ligand

BDBM50358645

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_789431 (CHEMBL1924407)

IC50

0.41±n/a nM

Citation

Liu, T; Nedrow-Byers, JR; Hopkins, MR; Berkman, CE Spacer length effects on in vitro imaging and surface accessibility of fluorescent inhibitors of prostate specific membrane antigen. Bioorg Med Chem Lett21:7013-6 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Glutamate carboxypeptidase 2

Name:

Glutamate carboxypeptidase 2

Synonyms:

Type:

PROTEIN

Mol. Mass.:

84333.66

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1497035

Residue:

750

Sequence:

MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKA
FLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYP
NKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYA
RTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVK
SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYY
DAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIG
TLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFAS
WDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKE
LKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKN
WETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDY
AVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIV
LRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVD
PSKAWGEVKRQIYVAAFTVQAAAETLSEVA

BDBM50358645

n/a

Name

BDBM50358645

Synonyms:

CHEMBL1921898

Type

Small organic molecule

Emp. Form.

C34H31N3O18P

Mol. Mass.

800.5936

SMILES

OC(=O)CC[C@H](NP(O)(=O)OC[C@H](NC(=O)CC[C@H](NC(=O)c1ccc(c(c1)C([O-])=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(O)=O)C(O)=O)C(O)=O |r,wU:18.18,wD:12.12,5.5,(11.85,-15.93,;11.85,-14.39,;13.19,-13.62,;10.52,-13.62,;9.19,-14.39,;7.85,-13.62,;6.52,-14.39,;5.19,-13.63,;5.17,-15.16,;3.86,-14.4,;5.19,-12.09,;3.86,-11.32,;3.86,-9.78,;2.52,-9.01,;1.19,-9.78,;1.19,-11.32,;-.14,-9.02,;-1.48,-9.79,;-2.81,-9.02,;-2.81,-7.48,;-4.14,-6.71,;-5.47,-7.48,;-4.14,-5.17,;-5.48,-4.4,;-5.48,-2.87,;-4.14,-2.09,;-2.82,-2.86,;-2.81,-4.39,;-1.48,-2.09,;-.15,-2.85,;-2.58,-.99,;-4.14,-.56,;-5.48,.21,;-6.81,-.55,;-8.14,.22,;-8.14,1.76,;-9.47,2.53,;-6.81,2.53,;-5.48,1.77,;-4.14,2.55,;-2.79,1.77,;-1.46,2.54,;-.13,1.77,;1.2,2.54,;-.12,.22,;-1.46,-.56,;-2.8,.22,;-4.14,-9.79,;-5.47,-9.02,;-4.14,-11.33,;5.18,-9.01,;6.52,-9.78,;5.18,-7.47,;7.85,-12.09,;9.18,-11.31,;6.52,-11.31,)|

Structure