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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | C-C chemokine receptor type 2 | ||
| Ligand | BDBM50359100 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
| IC50 | 270±n/a nM | ||
| Citation |  Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| C-C chemokine receptor type 2 | |||
| Name: | C-C chemokine receptor type 2 | ||
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41932.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41597 | ||
| Residue: | 374 | ||
| Sequence: |
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| BDBM50359100 | |||
| n/a | |||
| Name | BDBM50359100 | ||
| Synonyms: | CHEMBL1922815 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H35FN4O2 | ||
| Mol. Mass. | 502.6229 | ||
| SMILES | NC(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)\C=C\c1ccccc1F |(59.3,-8.57,;60.63,-9.35,;61.96,-8.58,;60.62,-10.89,;59.29,-11.65,;59.29,-13.19,;57.95,-13.95,;57.94,-15.49,;59.27,-16.26,;60.61,-15.5,;60.62,-13.95,;59.27,-17.8,;58.03,-18.71,;58.51,-20.18,;60.04,-20.17,;61.07,-21.31,;62.57,-20.99,;63.04,-19.52,;62.01,-18.38,;60.52,-18.7,;61.96,-11.66,;61.94,-13.2,;63.27,-13.97,;64.61,-13.21,;64.61,-11.67,;63.28,-10.89,;65.93,-13.99,;65.92,-15.53,;67.27,-13.23,;68.6,-14.01,;69.94,-13.25,;69.94,-11.72,;71.27,-10.95,;72.61,-11.73,;72.6,-13.27,;71.26,-14.03,;71.25,-15.57,)| | ||
| Structure | 
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