Reaction Details | |||
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Target | C-C chemokine receptor type 2 | ||
Ligand | BDBM50359117 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
IC50 | 640±n/a nM | ||
Citation | Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
C-C chemokine receptor type 2 | |||
Name: | C-C chemokine receptor type 2 | ||
Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
Type: | Enzyme | ||
Mol. Mass.: | 41932.32 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P41597 | ||
Residue: | 374 | ||
Sequence: |
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BDBM50359117 | |||
n/a | |||
Name | BDBM50359117 | ||
Synonyms: | CHEMBL1922799 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H33F3N4O3 | ||
Mol. Mass. | 530.5818 | ||
SMILES | COc1ccc(cn1)C1CCC(CC1)NC(C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1)C(N)=O |(28.92,-24.66,;30.25,-23.9,;30.26,-22.36,;28.92,-21.58,;28.93,-20.04,;30.27,-19.28,;31.6,-20.05,;31.6,-21.58,;30.28,-17.74,;28.95,-16.96,;28.95,-15.43,;30.29,-14.67,;31.62,-15.43,;31.62,-16.97,;30.29,-13.13,;31.63,-12.36,;32.96,-13.14,;32.95,-14.68,;34.27,-15.45,;35.61,-14.69,;35.62,-13.15,;34.29,-12.37,;36.94,-15.47,;36.93,-17.01,;38.28,-14.71,;39.61,-15.49,;40.94,-14.73,;40.95,-13.2,;42.28,-12.43,;42.28,-10.89,;43.62,-13.21,;44.95,-12.45,;43.6,-14.75,;44.93,-15.53,;42.27,-15.51,;31.63,-10.82,;30.3,-10.05,;32.97,-10.06,)| | ||
Structure |