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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | C-C chemokine receptor type 2 | ||
| Ligand | BDBM50359122 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
| IC50 | 130±n/a nM | ||
| Citation |  Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| C-C chemokine receptor type 2 | |||
| Name: | C-C chemokine receptor type 2 | ||
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41932.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41597 | ||
| Residue: | 374 | ||
| Sequence: |
| ||
| BDBM50359122 | |||
| n/a | |||
| Name | BDBM50359122 | ||
| Synonyms: | CHEMBL1922794 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H32F3N5O2 | ||
| Mol. Mass. | 539.5919 | ||
| SMILES | NC(=O)C(NC1CCC(CC1)c1c[nH]c2ncccc12)C1CCN(CC1)C(=O)C=Cc1cc(F)c(F)c(F)c1 |w:28.31,(11.21,5.58,;12.54,4.81,;13.87,5.58,;12.53,3.27,;11.2,2.5,;11.2,.96,;9.86,.2,;9.85,-1.33,;11.18,-2.11,;12.52,-1.34,;12.53,.2,;11.18,-3.65,;9.94,-4.56,;10.42,-6.02,;11.95,-6.01,;12.98,-7.15,;14.48,-6.83,;14.95,-5.36,;13.92,-4.23,;12.43,-4.55,;13.87,2.5,;13.85,.95,;15.18,.18,;16.52,.94,;16.52,2.48,;15.19,3.26,;17.84,.16,;17.83,-1.38,;19.18,.92,;20.51,.14,;21.85,.9,;21.85,2.44,;23.18,3.2,;23.19,4.74,;24.52,2.42,;25.86,3.19,;24.51,.88,;25.84,.1,;23.17,.12,)| | ||
| Structure | 
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