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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | C-C chemokine receptor type 2 | ||
| Ligand | BDBM50359125 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
| IC50 | 980±n/a nM | ||
| Citation |  Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| C-C chemokine receptor type 2 | |||
| Name: | C-C chemokine receptor type 2 | ||
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41932.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41597 | ||
| Residue: | 374 | ||
| Sequence: |
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| BDBM50359125 | |||
| n/a | |||
| Name | BDBM50359125 | ||
| Synonyms: | CHEMBL1922791 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C32H37F3N4O2 | ||
| Mol. Mass. | 566.657 | ||
| SMILES | CN(C)C(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1 |(14.23,-36.62,;14.22,-38.16,;12.89,-38.92,;15.56,-38.93,;16.89,-38.17,;15.55,-40.47,;14.22,-41.24,;14.22,-42.78,;12.88,-43.54,;12.87,-45.07,;14.2,-45.85,;15.54,-45.08,;15.55,-43.54,;14.2,-47.39,;12.95,-48.3,;13.43,-49.76,;14.97,-49.75,;16,-50.89,;17.5,-50.57,;17.97,-49.1,;16.94,-47.97,;15.45,-48.29,;16.88,-41.25,;16.87,-42.79,;18.19,-43.56,;19.53,-42.8,;19.54,-41.26,;18.21,-40.48,;20.86,-43.58,;20.85,-45.12,;22.2,-42.82,;23.53,-43.6,;24.87,-42.84,;24.87,-41.31,;26.2,-40.54,;26.21,-39,;27.54,-41.32,;28.88,-40.56,;27.53,-42.86,;28.86,-43.64,;26.19,-43.62,)| | ||
| Structure | 
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