| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cell division protein FtsZ |
|---|
| Ligand | BDBM50359415 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_793371 (CHEMBL1931925) |
|---|
| IC50 | 46200±n/a nM |
|---|
| Citation |  Mathew, B; Srivastava, S; Ross, LJ; Suling, WJ; White, EL; Woolhiser, LK; Lenaerts, AJ; Reynolds, RC Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors. Bioorg Med Chem19:7120-8 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cell division protein FtsZ |
|---|
| Name: | Cell division protein FtsZ |
|---|
| Synonyms: | FTSZ_MYCTU | ftsZ |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 38736.30 |
|---|
| Organism: | Mycobacterium tuberculosis |
|---|
| Description: | ChEMBL_1470459 |
|---|
| Residue: | 379 |
|---|
| Sequence: | MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDAQALLMSDADVKLDVGR
DSTRGLGAGADPEVGRKAAEDAKDEIEELLRGADMVFVTAGEGGGTGTGGAPVVASIARK
LGALTVGVVTRPFSFEGKRRSNQAENGIAALRESCDTLIVIPNDRLLQMGDAAVSLMDAF
RSADEVLLNGVQGITDLITTPGLINVDFADVKGIMSGAGTALMGIGSARGEGRSLKAAEI
AINSPLLEASMEGAQGVLMSIAGGSDLGLFEINEAASLVQDAAHPDANIIFGTVIDDSLG
DEVRVTVIAAGFDVSGPGRKPVMGETGGAHRIESAKAGKLTSTLFEPVDAVSVPLHTNGA
TLSIGGDDDDVDVPPFMRR
|
|
|
|---|
| BDBM50359415 |
|---|
| n/a |
|---|
| Name | BDBM50359415 |
|---|
| Synonyms: | CHEMBL1926727 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H36N6O2S |
|---|
| Mol. Mass. | 532.7 |
|---|
| SMILES | CCOC(=O)Nc1nc(NCCCCN(CC)CC)c2N=C(C(Sc2n1)c1ccccc1)c1ccccc1 |c:20| |
|---|
| Structure | 
|
|---|
Search and Browse
