| Reaction Details |
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 | Report a problem with these data |
| Target | NADPH oxidase 1 |
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| Ligand | BDBM50359528 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_792877 (CHEMBL1931062) |
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| Ki | 87±n/a nM |
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| Citation |  Gaggini, F; Laleu, B; Orchard, M; Fioraso-Cartier, L; Cagnon, L; Houngninou-Molango, S; Gradia, A; Duboux, G; Merlot, C; Heitz, F; Szyndralewiez, C; Page, P Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors. Bioorg Med Chem19:6989-99 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NADPH oxidase 1 |
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| Name: | NADPH oxidase 1 |
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| Synonyms: | MOX-1 | MOX1 | Mitogenic oxidase 1 | NADH/NADPH mitogenic oxidase subunit P65-MOX | NOH-1 | NOH1 | NOX-1 | NOX1 | NOX1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64890.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_792877 |
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| Residue: | 564 |
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| Sequence: | MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCL
NFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHL
FNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVI
MTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHP
RKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKV
VMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGD
WTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYK
FQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSN
IVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSL
RKCCHRYSSLDPRKVQFYFNKENF
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| BDBM50359528 |
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| n/a |
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| Name | BDBM50359528 |
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| Synonyms: | CHEMBL1927149 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20Cl2N4O2 |
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| Mol. Mass. | 455.337 |
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| SMILES | Clc1ccccc1CN1CCCn2c(C1)c1c(cc2=O)[nH]n(-c2ccccc2Cl)c1=O |
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| Structure | 
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