Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50360474 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_795613 (CHEMBL1936043) | ||
| Ki | 52±n/a nM | ||
| Citation |  Abid Masood, M; Farrant, E; Morao, I; Bazin, M; Perez, M; Bunnage, ME; Fancy, SA; Peakman, T Lead diversification. Application to existing drug molecules: mifepristone 1 and antalarmin 8. Bioorg Med Chem Lett22:723-8 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
| ||
| BDBM50360474 | |||
| n/a | |||
| Name | BDBM50360474 | ||
| Synonyms: | CHEMBL1934750 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H32N4O | ||
| Mol. Mass. | 392.5371 | ||
| SMILES | CCCCN(CC)c1nc(C)nc2n(c(C=O)c(C)c12)-c1c(C)cc(C)cc1C |(-9.11,-24.17,;-7.77,-23.4,;-6.44,-24.17,;-5.11,-23.4,;-3.77,-24.17,;-2.44,-23.4,;-2.44,-21.86,;-3.77,-25.71,;-5.1,-26.48,;-5.1,-28.02,;-6.43,-28.8,;-3.77,-28.79,;-2.44,-28.02,;-.97,-28.48,;-.08,-27.24,;1.46,-27.23,;2.22,-25.89,;-.99,-26,;-.52,-24.53,;-2.44,-26.48,;-.49,-29.94,;1.01,-30.25,;2.03,-29.1,;1.5,-31.71,;.47,-32.87,;.96,-34.33,;-1.04,-32.55,;-1.52,-31.09,;-3.03,-30.78,)| | ||
| Structure | 
| ||