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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50360475 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_795613 (CHEMBL1936043) | ||
| Ki | 11±n/a nM | ||
| Citation |  Abid Masood, M; Farrant, E; Morao, I; Bazin, M; Perez, M; Bunnage, ME; Fancy, SA; Peakman, T Lead diversification. Application to existing drug molecules: mifepristone 1 and antalarmin 8. Bioorg Med Chem Lett22:723-8 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50360475 | |||
| n/a | |||
| Name | BDBM50360475 | ||
| Synonyms: | CHEMBL1934751 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H36N4O | ||
| Mol. Mass. | 408.5795 | ||
| SMILES | CCCCN(CC)c1nc(C)nc2n(c(COC)c(C)c12)-c1c(C)cc(C)cc1C |(10.4,-24.1,;11.73,-23.33,;13.07,-24.1,;14.4,-23.33,;15.73,-24.1,;17.07,-23.33,;17.07,-21.79,;15.73,-25.64,;14.4,-26.41,;14.4,-27.95,;13.07,-28.73,;15.73,-28.72,;17.07,-27.95,;18.53,-28.41,;19.43,-27.17,;20.97,-27.16,;21.73,-25.82,;23.27,-25.81,;18.52,-25.93,;18.99,-24.46,;17.06,-26.41,;19.01,-29.87,;20.52,-30.18,;21.54,-29.03,;21.01,-31.64,;19.98,-32.8,;20.47,-34.26,;18.47,-32.48,;17.99,-31.02,;16.48,-30.71,)| | ||
| Structure | 
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