| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-activated protein kinase 2 |
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| Ligand | BDBM50360549 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_795360 (CHEMBL1937260) |
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| EC50 | 4.1±n/a nM |
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| Citation |  Oubrie, A; Kaptein, A; de Zwart, E; Hoogenboom, N; Goorden, R; van de Kar, B; van Hoek, M; de Kimpe, V; van der Heijden, R; Borsboom, J; Kazemier, B; de Roos, J; Scheffers, M; Lommerse, J; Schultz-Fademrecht, C; Barf, T Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series. Bioorg Med Chem Lett22:613-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP kinase-activated protein kinase 2 |
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| Name: | MAP kinase-activated protein kinase 2 |
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| Synonyms: | MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 45579.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49137 |
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| Residue: | 400 |
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| Sequence: | MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL
ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
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| BDBM50360549 |
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| n/a |
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| Name | BDBM50360549 |
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| Synonyms: | CHEMBL1933193 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20N6O2 |
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| Mol. Mass. | 388.4225 |
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| SMILES | O=C(Nc1cc(ccn1)-c1cc2c([nH]1)C1(CCNC1)CNC2=O)c1ccccn1 |
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| Structure | 
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