Ki Summary

Reaction Details

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Target

Prostaglandin E2 receptor EP4 subtype

Ligand

BDBM50156547

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_795669 (CHEMBL1936150)

1.7±n/a nM

Citation

Kambe, T; Maruyama, T; Nakano, M; Nakai, Y; Yoshida, T; Matsunaga, N; Oida, H; Konaka, A; Maruyama, T; Nakai, H; Toda, M Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivity. Bioorg Med Chem Lett22:396-401 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Prostaglandin E2 receptor EP4 subtype

Name:

Prostaglandin E2 receptor EP4 subtype

Synonyms:

PE2R4_MOUSE | PGE receptor, EP4 subtype | Prostanoid EP4 receptor | Ptger4 | Ptgerep4

Type:

G-protein coupled receptor

Mol. Mass.:

56175.66

Organism:

Mus musculus (Mouse)

Description:

n/a

Residue:

513

Sequence:

MAEVGGTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGN
LVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYS
TFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAIYASNVLFCALPN
MGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHR
QFMRRTSLGTEQHHAAAAAAVASVACRGHAGASPALQRLSDFRRRRSFRRIAGAEIQMVI
LLIATSLVVLICSIPLVVRVFINQLYQPNVVKDISRNPDLQAIRIASVNPILDPWIYILL
RKTVLSKAIEKIKCLFCRIGGSGRDSSAQHCSESRRTSSAMSGHSRSFLARELKEISSTS
QTLLYLPDLTESSLGGRNLLPGSHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVD
EVSGSHREEPASKGNSLQVTFPSETLKLSEKCI

BDBM50156547

n/a

Name

BDBM50156547

Synonyms:

4-(2-((R)-2-((S)-3-hydroxyoct-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)benzoate | 4-(2-((R)-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)benzoic acid | CHEMBL222715

Type

Small organic molecule

Emp. Form.

C21H29NO4

Mol. Mass.

359.4593

SMILES

CCCCC[C@H](O)\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O |r|

Structure