| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 6 |
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| Ligand | BDBM50361052 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_796061 (CHEMBL1936931) |
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| Ki | 9.8±n/a nM |
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| Citation |  Sundar, BG; Bailey, TR; Dunn, DD; Bacon, ER; Salvino, JM; Morton, GC; Aimone, LD; Zeqi, H; Mathiasen, JR; Dicamillo, A; Huffman, MJ; McKenna, BA; Kopec, K; Lu, LD; Brown, R; Qian, J; Angeles, T; Connors, T; Spais, C; Holskin, B; Galinis, D; Duzic, E; Schaffhauser, H; Rosse, GC Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists. Bioorg Med Chem Lett22:120-3 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 6 |
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| Name: | 5-hydroxytryptamine receptor 6 |
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| Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5HT6R_RAT | Htr6 | ST-B17 | Serotonin (5-HT) receptor | Serotonin 6 (5-HT6) receptor | Serotonin receptor 6 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 46945.51 |
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| Organism: | RAT |
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| Description: | 5-HT6 HTR6 RAT::P31388 |
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| Residue: | 436 |
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| Sequence: | MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQC
RLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVP
RTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVP
DQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLS
QTLWSLRYGRIHSVPP
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| BDBM50361052 |
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| n/a |
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| Name | BDBM50361052 |
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| Synonyms: | CHEMBL1935589 | CHEMBL1949758 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15NO3S |
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| Mol. Mass. | 313.371 |
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| SMILES | O=S(=O)(c1ccccc1)c1ccc2c3CCNCc3oc2c1 |
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| Structure | 
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