| Reaction Details |
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 | Report a problem with these data |
| Target | Protein phosphatase 1D |
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| Ligand | BDBM50361941 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_799042 (CHEMBL1941901) |
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| IC50 | 480±n/a nM |
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| Citation |  Yagi, H; Chuman, Y; Kozakai, Y; Imagawa, T; Takahashi, Y; Yoshimura, F; Tanino, K; Sakaguchi, K A small molecule inhibitor of p53-inducible protein phosphatase PPM1D. Bioorg Med Chem Lett22:729-32 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein phosphatase 1D |
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| Name: | Protein phosphatase 1D |
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| Synonyms: | PP2C-delta | PPM1D | PPM1D_HUMAN | Protein phosphatase 2C isoform delta | Protein phosphatase magnesium-dependent 1 delta | WIP1 | p53-induced protein phosphatase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66695.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1515094 |
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| Residue: | 605 |
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| Sequence: | MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPG
GEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHL
WGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVII
RGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSG
VNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHT
LDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQ
RMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVK
SLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAK
ALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEE
SNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRK
TVCVC
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| BDBM50361941 |
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| n/a |
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| Name | BDBM50361941 |
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| Synonyms: | CHEMBL1939361 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H60O4Si2 |
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| Mol. Mass. | 540.966 |
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| SMILES | CC[Si](CC)(CC)O[C@@H]1C[C@H](C)C[C@@H]2[C@@H]1C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1[C@](C)(CO)C[C@H](O)C[C@@]21C |r| |
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| Structure | 
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