| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk2 |
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| Ligand | BDBM50025098 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_801825 (CHEMBL1947437) |
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| IC50 | 8±n/a nM |
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| Citation |  Saleem, RS; Lansdell, TA; Tepe, JJ Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors. Bioorg Med Chem20:1475-81 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Chk2 |
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| Name: | Serine/threonine-protein kinase Chk2 |
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| Synonyms: | CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2 |
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| Type: | Protein |
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| Mol. Mass.: | 60908.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O96017 |
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| Residue: | 543 |
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| Sequence: | MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE
DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
AVL
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| BDBM50025098 |
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| n/a |
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| Name | BDBM50025098 |
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| Synonyms: | CHEMBL332551 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13N5O2 |
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| Mol. Mass. | 295.296 |
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| SMILES | Nc1nc(c(O)[nH]1)C1=C2C(=Nc3ccccc23)C(=O)NCC1 |c:10,t:8| |
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| Structure | 
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