| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily A member 1 |
|---|
| Ligand | BDBM50305207 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_802303 (CHEMBL1949461) |
|---|
| IC50 | 3400±n/a nM |
|---|
| Citation |  Baraldi, PG; Romagnoli, R; Saponaro, G; Aghazadeh Tabrizi, M; Baraldi, S; Pedretti, P; Fusi, C; Nassini, R; Materazzi, S; Geppetti, P; Preti, D 7-Substituted-pyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: a promising approach for treating pain and inflammation. Bioorg Med Chem20:1690-8 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transient receptor potential cation channel subfamily A member 1 |
|---|
| Name: | Transient receptor potential cation channel subfamily A member 1 |
|---|
| Synonyms: | Anktm1 | TRPA1_RAT | Trpa1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 128622.74 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1450487 |
|---|
| Residue: | 1125 |
|---|
| Sequence: | MKRSLRRVLRPEERKEVQGVVYRGVGKDMDCSKESFKVDIEGDMCRLEAFIKNRRKLSKY
EDENLCLLHHAAAEGQVELMQLIINGSSCEALNVMDDYGNTPLHWAAEKNQVESVKFLLS
QGANPNLRNRNMMAPLHIAVQGMYNEVIKVLTEHKATNINLEGENGNTALMSTCAKDNSE
ALQILLEKGAKLCKSNKWGDYPVHQAAFSGAKRCMELILAYGEKTGYSREAHINFVNHKK
ASPLHLAVQSGDLDMIKMCLDSGAHIDMMENAKCMALHFAATQGATDIVKLMISSYTGSS
DIVNAVDGNQETLLHRASLFDHHDLADYLISVGADINSTDSEGRSPLILATASASWNIVN
LLLSKGAKVDIKDHLGRNFLHLTVQQPYGLRNLRPEFLQMQHIKELVMDEDNDGCTPLHY
ACRQGAPVSVNNLLRFNVSVHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD
LHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLK
CTDRLDEEGNTALHFAAREGHAKAVAMLLSYNADILLNKKQASFLHIALHNKRKEVVLTT
IRSKRWDECLQVFTHDSPSNRCPIMEMVEYLPECMKVLLDFCMIPSTEDKSCQDYHIEYN
FKYLQCPLSMTKKVTPTQDVIYEPLTILNVMVQHNRIELLNHPVCREYLLMKWCAYGFRA
HMMNLGSYCLGLIPMTLLVVKIQPGMAFNSTGIINETISTHEERINTLNSFPLKICMILV
FLSSIFGYCKEVVQIFQQKRNYFLDYNNALEWVIYTTSMIFVLPLFLDIPAYMQWQCGAI
AIFFYWMNFLLYLQRFENCGIFIVMLEVIFKTLLRSTGVFIFLLLAFGLSFYVLLNFQDA
FSTPLLSLIQTFSMMLGDINYRDAFLEPLFRNELAYPVLTFGQLIAFTMFVPIVLMNLLI
GLAVGDIAEVQKHASLKRIAMQVELHTNLEKKLPFWYLRKVDQRSTIVYPNRPRHGRMLR
FFHYFLSMQETRQEAPNIDTCLEMEILKQKYRLKDLTSLLEKQHELIKLIIQKMEIISET
EDEDNHCSFQDRFKKERLEQMHSKWNFVLNAVKTKTHCSISHPDI
|
|
|
|---|
| BDBM50305207 |
|---|
| n/a |
|---|
| Name | BDBM50305207 |
|---|
| Synonyms: | 4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime | CHEMBL593902 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H12ClNO |
|---|
| Mol. Mass. | 209.672 |
|---|
| SMILES | CC(N=O)C(C)=Cc1ccc(Cl)cc1 |w:6.6| |
|---|
| Structure | 
|
|---|
Search and Browse
