| Reaction Details |
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 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily A member 1 |
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| Ligand | BDBM50362753 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_802303 (CHEMBL1949461) |
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| IC50 | 3800±n/a nM |
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| Citation |  Baraldi, PG; Romagnoli, R; Saponaro, G; Aghazadeh Tabrizi, M; Baraldi, S; Pedretti, P; Fusi, C; Nassini, R; Materazzi, S; Geppetti, P; Preti, D 7-Substituted-pyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: a promising approach for treating pain and inflammation. Bioorg Med Chem20:1690-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transient receptor potential cation channel subfamily A member 1 |
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| Name: | Transient receptor potential cation channel subfamily A member 1 |
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| Synonyms: | Anktm1 | TRPA1_RAT | Trpa1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 128622.74 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1450487 |
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| Residue: | 1125 |
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| Sequence: | MKRSLRRVLRPEERKEVQGVVYRGVGKDMDCSKESFKVDIEGDMCRLEAFIKNRRKLSKY
EDENLCLLHHAAAEGQVELMQLIINGSSCEALNVMDDYGNTPLHWAAEKNQVESVKFLLS
QGANPNLRNRNMMAPLHIAVQGMYNEVIKVLTEHKATNINLEGENGNTALMSTCAKDNSE
ALQILLEKGAKLCKSNKWGDYPVHQAAFSGAKRCMELILAYGEKTGYSREAHINFVNHKK
ASPLHLAVQSGDLDMIKMCLDSGAHIDMMENAKCMALHFAATQGATDIVKLMISSYTGSS
DIVNAVDGNQETLLHRASLFDHHDLADYLISVGADINSTDSEGRSPLILATASASWNIVN
LLLSKGAKVDIKDHLGRNFLHLTVQQPYGLRNLRPEFLQMQHIKELVMDEDNDGCTPLHY
ACRQGAPVSVNNLLRFNVSVHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD
LHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLK
CTDRLDEEGNTALHFAAREGHAKAVAMLLSYNADILLNKKQASFLHIALHNKRKEVVLTT
IRSKRWDECLQVFTHDSPSNRCPIMEMVEYLPECMKVLLDFCMIPSTEDKSCQDYHIEYN
FKYLQCPLSMTKKVTPTQDVIYEPLTILNVMVQHNRIELLNHPVCREYLLMKWCAYGFRA
HMMNLGSYCLGLIPMTLLVVKIQPGMAFNSTGIINETISTHEERINTLNSFPLKICMILV
FLSSIFGYCKEVVQIFQQKRNYFLDYNNALEWVIYTTSMIFVLPLFLDIPAYMQWQCGAI
AIFFYWMNFLLYLQRFENCGIFIVMLEVIFKTLLRSTGVFIFLLLAFGLSFYVLLNFQDA
FSTPLLSLIQTFSMMLGDINYRDAFLEPLFRNELAYPVLTFGQLIAFTMFVPIVLMNLLI
GLAVGDIAEVQKHASLKRIAMQVELHTNLEKKLPFWYLRKVDQRSTIVYPNRPRHGRMLR
FFHYFLSMQETRQEAPNIDTCLEMEILKQKYRLKDLTSLLEKQHELIKLIIQKMEIISET
EDEDNHCSFQDRFKKERLEQMHSKWNFVLNAVKTKTHCSISHPDI
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| BDBM50362753 |
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| n/a |
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| Name | BDBM50362753 |
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| Synonyms: | CHEMBL1939978 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14N2O2S |
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| Mol. Mass. | 322.381 |
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| SMILES | COc1cccc(c1)C1NC(=S)N=C2C1C(=O)c1ccccc21 |c:13| |
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| Structure | 
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