Reaction Details | |||
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Target | Potassium voltage-gated channel subfamily H member 2 | ||
Ligand | BDBM50363946 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_802791 (CHEMBL1953525) | ||
IC50 | >30±n/a nM | ||
Citation | Xue, CB; Feng, H; Cao, G; Huang, T; Glenn, J; Anand, R; Meloni, D; Zhang, K; Kong, L; Wang, A; Zhang, Y; Zheng, C; Xia, M; Chen, L; Tanaka, H; Han, Q; Robinson, DJ; Modi, D; Storace, L; Shao, L; Sharief, V; Li, M; Galya, LG; Covington, M; Scherle, P; Diamond, S; Emm, T; Yeleswaram, S; Contel, N; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist. ACS Med Chem Lett2:450-454 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Potassium voltage-gated channel subfamily H member 2 | |||
Name: | Potassium voltage-gated channel subfamily H member 2 | ||
Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
Type: | Multi-pass membrane protein | ||
Mol. Mass.: | 126672.65 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q12809 | ||
Residue: | 1159 | ||
Sequence: |
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BDBM50363946 | |||
n/a | |||
Name | BDBM50363946 | ||
Synonyms: | CHEMBL1951771 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H28F3N5O3 | ||
Mol. Mass. | 491.506 | ||
SMILES | O[C@]1(CC[C@@H](CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)c1ncccn1 |r,wU:4.7,wD:10.13,1.0,(-5.61,-27.39,;-4.83,-28.74,;-4.02,-30.05,;-2.49,-30.02,;-1.74,-28.67,;-2.54,-27.35,;-4.09,-27.38,;-.2,-28.64,;.72,-29.87,;2.17,-29.36,;2.14,-27.82,;.67,-27.38,;3.47,-27.04,;4.81,-27.79,;4.83,-29.33,;6.14,-27,;7.48,-27.76,;8.8,-26.97,;8.78,-25.43,;10.15,-27.72,;10.16,-29.26,;11.5,-30.02,;12.82,-29.23,;12.8,-27.68,;11.46,-26.93,;14.12,-26.89,;15.47,-27.64,;14.1,-25.35,;15.45,-26.11,;-6.37,-28.77,;-7.17,-27.46,;-8.71,-27.49,;-9.45,-28.84,;-8.66,-30.16,;-7.11,-30.13,)| | ||
Structure |