Reaction Details |
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Target | E3 ubiquitin-protein ligase XIAP |
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Ligand | BDBM50364485 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_802614 (CHEMBL1952921) |
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IC50 | 280±n/a nM |
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Citation | Hennessy, EJ; Saeh, JC; Sha, L; MacIntyre, T; Wang, H; Larsen, NA; Aquila, BM; Ferguson, AD; Laing, NM; Omer, CA Discovery of aminopiperidine-based Smac mimetics as IAP antagonists. Bioorg Med Chem Lett22:1690-4 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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E3 ubiquitin-protein ligase XIAP |
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Name: | E3 ubiquitin-protein ligase XIAP |
Synonyms: | API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN |
Type: | Protein |
Mol. Mass.: | 56685.27 |
Organism: | Homo sapiens (Human) |
Description: | P98170 |
Residue: | 497 |
Sequence: | MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
CPMCYTVITFKQKIFMS
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BDBM50364485 |
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n/a |
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Name | BDBM50364485 |
Synonyms: | CHEMBL1950720 |
Type | Small organic molecule |
Emp. Form. | C27H42N4O2 |
Mol. Mass. | 454.648 |
SMILES | CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CC[C@H]2CCN(CCc3ccccc3)C[C@@H]12 |r| |
Structure |
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