Reaction Details | |||
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Target | Serine/threonine-protein kinase pim-2 | ||
Ligand | BDBM50364794 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_803131 (CHEMBL1954567) | ||
IC50 | 69±n/a nM | ||
Citation | Pastor, J; Oyarzabal, J; Saluste, G; Alvarez, RM; Rivero, V; Ramos, F; Cendón, E; Blanco-Aparicio, C; Ajenjo, N; Cebriá, A; Albarrán, MI; Cebrián, D; Corrionero, A; Fominaya, J; Montoya, G; Mazzorana, M Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors. Bioorg Med Chem Lett22:1591-7 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase pim-2 | |||
Name: | Serine/threonine-protein kinase pim-2 | ||
Synonyms: | PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2) | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 34185.93 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9P1W9 | ||
Residue: | 311 | ||
Sequence: |
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BDBM50364794 | |||
n/a | |||
Name | BDBM50364794 | ||
Synonyms: | CHEMBL1952132 | ||
Type | Small organic molecule | ||
Emp. Form. | C18H18F3N5O2 | ||
Mol. Mass. | 393.363 | ||
SMILES | O[C@H]1CC[C@@H](CC1)Nc1ccc2nnn(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:4.7,wD:1.0,(29.89,-28.84,;29.9,-27.3,;31.24,-26.54,;31.24,-24.99,;29.91,-24.22,;28.57,-24.99,;28.57,-26.53,;29.92,-22.68,;31.25,-21.91,;31.25,-20.37,;32.58,-19.6,;33.91,-20.36,;35.39,-19.88,;36.3,-21.14,;35.39,-22.39,;36.15,-23.72,;35.37,-25.05,;36.12,-26.39,;37.66,-26.4,;38.44,-25.07,;39.98,-25.07,;40.75,-26.41,;42.29,-26.41,;39.97,-27.74,;41.51,-27.73,;37.68,-23.73,;33.92,-21.91,;32.58,-22.68,)| | ||
Structure |