Reaction Details |
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Target | Bifunctional protein GlmU |
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Ligand | BDBM50365069 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_804877 (CHEMBL1953925) |
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IC50 | >200000±n/a nM |
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Citation | Green, OM; McKenzie, AR; Shapiro, AB; Otterbein, L; Ni, H; Patten, A; Stokes, S; Albert, R; Kawatkar, S; Breed, J Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series. Bioorg Med Chem Lett22:1510-9 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bifunctional protein GlmU |
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Name: | Bifunctional protein GlmU |
Synonyms: | GLMU_STRPN | Glucosamine-1-phosphate N-acetyltransferase | N-acetylglucosamine-1-phosphate uridyltransferase | UDP-N-acetylglucosamine pyrophosphorylase | glmU |
Type: | PROTEIN |
Mol. Mass.: | 49335.99 |
Organism: | Streptococcus pneumoniae |
Description: | ChEMBL_804877 |
Residue: | 459 |
Sequence: | MSNFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQPEKTVTVVGHKAELVE
EVLAGQTEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAGDTPLITGESLKNLIDFHIN
HKNVATILTAETDNPFGYGRIVRNDNAEVLRIVEQKDATDFEKQIKEINTGTYVFDNERL
FEALKNINTNNAQGEYYITDVIGIFRETGEKVGAYTLKDFDESLGVNDRVALATAESVMR
RRINHKHMVNGVSFVNPEATYIDIDVEIASEVQIEANVTLKGQTKIGAETVLTNGTYVVD
STIGAGAVITNSMIEESSVADGVIVGPYAHIRPNSSLGAQVHIGNFVEVKGSSIGENTKA
GHLTYIGNCEVGSNVNFGAGTITVNYDGKNKYKTVIGNNVFVGSNSTIIAPVELGDNSLV
GAGSTITKDVPADAIAIGRGRQINKDEYATRLPHHPKNQ
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BDBM50365069 |
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n/a |
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Name | BDBM50365069 |
Synonyms: | CHEMBL1951080 |
Type | Small organic molecule |
Emp. Form. | C22H26N2O7S2 |
Mol. Mass. | 494.581 |
SMILES | COc1cc(OC)c(cc1NC(=O)CSCC(O)=O)S(=O)(=O)N1C(C)CCc2ccccc12 |
Structure |
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