| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bifunctional protein GlmU |
|---|
| Ligand | BDBM50365090 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_804877 (CHEMBL1953925) |
|---|
| IC50 | >200000±n/a nM |
|---|
| Citation |  Green, OM; McKenzie, AR; Shapiro, AB; Otterbein, L; Ni, H; Patten, A; Stokes, S; Albert, R; Kawatkar, S; Breed, J Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series. Bioorg Med Chem Lett22:1510-9 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bifunctional protein GlmU |
|---|
| Name: | Bifunctional protein GlmU |
|---|
| Synonyms: | GLMU_STRPN | Glucosamine-1-phosphate N-acetyltransferase | N-acetylglucosamine-1-phosphate uridyltransferase | UDP-N-acetylglucosamine pyrophosphorylase | glmU |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 49335.99 |
|---|
| Organism: | Streptococcus pneumoniae |
|---|
| Description: | ChEMBL_804877 |
|---|
| Residue: | 459 |
|---|
| Sequence: | MSNFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQPEKTVTVVGHKAELVE
EVLAGQTEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAGDTPLITGESLKNLIDFHIN
HKNVATILTAETDNPFGYGRIVRNDNAEVLRIVEQKDATDFEKQIKEINTGTYVFDNERL
FEALKNINTNNAQGEYYITDVIGIFRETGEKVGAYTLKDFDESLGVNDRVALATAESVMR
RRINHKHMVNGVSFVNPEATYIDIDVEIASEVQIEANVTLKGQTKIGAETVLTNGTYVVD
STIGAGAVITNSMIEESSVADGVIVGPYAHIRPNSSLGAQVHIGNFVEVKGSSIGENTKA
GHLTYIGNCEVGSNVNFGAGTITVNYDGKNKYKTVIGNNVFVGSNSTIIAPVELGDNSLV
GAGSTITKDVPADAIAIGRGRQINKDEYATRLPHHPKNQ
|
|
|
|---|
| BDBM50365090 |
|---|
| n/a |
|---|
| Name | BDBM50365090 |
|---|
| Synonyms: | CHEMBL1951179 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H22N2O7S |
|---|
| Mol. Mass. | 422.452 |
|---|
| SMILES | COC(=O)c1ccccc1CNS(=O)(=O)c1cc(NC(C)=O)c(OC)cc1OC |
|---|
| Structure | 
|
|---|
Search and Browse
