| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional protein GlmU |
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| Ligand | BDBM50365097 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_804877 (CHEMBL1953925) |
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| IC50 | 2000±n/a nM |
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| Citation |  Green, OM; McKenzie, AR; Shapiro, AB; Otterbein, L; Ni, H; Patten, A; Stokes, S; Albert, R; Kawatkar, S; Breed, J Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series. Bioorg Med Chem Lett22:1510-9 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional protein GlmU |
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| Name: | Bifunctional protein GlmU |
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| Synonyms: | GLMU_STRPN | Glucosamine-1-phosphate N-acetyltransferase | N-acetylglucosamine-1-phosphate uridyltransferase | UDP-N-acetylglucosamine pyrophosphorylase | glmU |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49335.99 |
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| Organism: | Streptococcus pneumoniae |
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| Description: | ChEMBL_804877 |
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| Residue: | 459 |
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| Sequence: | MSNFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQPEKTVTVVGHKAELVE
EVLAGQTEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAGDTPLITGESLKNLIDFHIN
HKNVATILTAETDNPFGYGRIVRNDNAEVLRIVEQKDATDFEKQIKEINTGTYVFDNERL
FEALKNINTNNAQGEYYITDVIGIFRETGEKVGAYTLKDFDESLGVNDRVALATAESVMR
RRINHKHMVNGVSFVNPEATYIDIDVEIASEVQIEANVTLKGQTKIGAETVLTNGTYVVD
STIGAGAVITNSMIEESSVADGVIVGPYAHIRPNSSLGAQVHIGNFVEVKGSSIGENTKA
GHLTYIGNCEVGSNVNFGAGTITVNYDGKNKYKTVIGNNVFVGSNSTIIAPVELGDNSLV
GAGSTITKDVPADAIAIGRGRQINKDEYATRLPHHPKNQ
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| BDBM50365097 |
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| n/a |
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| Name | BDBM50365097 |
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| Synonyms: | CHEMBL1951186 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H31N3O9S |
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| Mol. Mass. | 549.593 |
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| SMILES | COc1cc(OC)c(cc1NC(=O)CCC(O)=O)S(=O)(=O)NCc1ccccc1N1CCC(CC1)C(O)=O |
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| Structure | 
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