| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
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| Ligand | BDBM71742 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_808113 (CHEMBL1961264) |
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| Ki | 9130±n/a nM |
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| Citation |  Carta, F; Maresca, A; Scozzafava, A; Supuran, CT Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII. Bioorg Med Chem20:2266-73 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 12 |
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| Name: | Carbonic anhydrase 12 |
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| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39456.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Catalytic domain of human cloned isozyme was used in the assay |
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| Residue: | 354 |
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| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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| BDBM71742 |
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| n/a |
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| Name | BDBM71742 |
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| Synonyms: | 7-amino-4-methyl-1-benzopyran-2-one | 7-amino-4-methyl-coumarin | 7-amino-4-methylchromen-2-one | 7-azanyl-4-methyl-chromen-2-one | EN300-05587 | MLS000057660 | SMR000067752 | cid_92249 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H9NO2 |
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| Mol. Mass. | 175.184 |
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| SMILES | Cc1cc(=O)oc2cc(N)ccc12 |
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| Structure | 
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