| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor subfamily 1 group D member 2 |
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| Ligand | BDBM50366239 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_808915 (CHEMBL1961799) |
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| IC50 | 560±n/a nM |
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| Citation |  Solt, LA; Wang, Y; Banerjee, S; Hughes, T; Kojetin, DJ; Lundasen, T; Shin, Y; Liu, J; Cameron, MD; Noel, R; Yoo, SH; Takahashi, JS; Butler, AA; Kamenecka, TM; Burris, TP Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature485:62-68 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor subfamily 1 group D member 2 |
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| Name: | Nuclear receptor subfamily 1 group D member 2 |
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| Synonyms: | EAR-1R | NR1D2 | NR1D2_HUMAN | Orphan nuclear hormone receptor BD73 | Rev-erb-beta | V-erbA-related protein 1-related |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64639.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1502200 |
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| Residue: | 579 |
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| Sequence: | MEVNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNSDTNGNPKNGDL
ANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHAC
EGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIP
KREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKS
SSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDH
CGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPI
DGFSQNENKNSYLCNTGGRMHLVCPLSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFA
KRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAG
DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLI
MKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP
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| BDBM50366239 |
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| n/a |
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| Name | BDBM50366239 |
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| Synonyms: | CHEMBL1961797 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H31ClN4O3S |
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| Mol. Mass. | 479.035 |
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| SMILES | CCCCCNC(=O)N1CCC(CN(Cc2ccc(s2)[N+]([O-])=O)Cc2ccc(Cl)cc2)C1 |
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| Structure | 
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