| Reaction Details |
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 | Report a problem with these data |
| Target | Leukotriene A-4 hydrolase |
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| Ligand | BDBM50022752 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_96937 |
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| IC50 | >250000±n/a nM |
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| Citation |  Yuan, W; Zhong, Z; Wong, C; Haeggstrom, JZ; Wetterholm, A; Samuelsson, B Probing the inhibition of leukotriene A4 hydrolase based on its aminopeptidase activity Bioorg Med Chem Lett1:551-556 (1991) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Leukotriene A-4 hydrolase |
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| Name: | Leukotriene A-4 hydrolase |
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| Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
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| Type: | Hydrolase; metalloprotease |
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| Mol. Mass.: | 69280.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant LTA4H. |
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| Residue: | 611 |
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| Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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| BDBM50022752 |
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| n/a |
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| Name | BDBM50022752 |
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| Synonyms: | (R)-3-Amino-2-mercapto-4-phenyl-butyric acid methyl ester | 3-Amino-2-mercapto-4-phenyl-butyric acid methyl ester | CHEMBL68092 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H15NO2S |
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| Mol. Mass. | 225.307 |
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| SMILES | COC(=O)C(S)[C@H](N)Cc1ccccc1 |
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| Structure | 
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