| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene synthase |
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| Ligand | BDBM50281076 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_202106 |
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| IC50 | 31500±n/a nM |
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| Citation |  Watson, NS; Bell, R; Chan, C; Cox, B; Hutson, JL; Keeling, SE; Kirk, BE; Procopiou, PA; Steeples, IP; Widdowson, J The squalestatins: potent inhibitors of squalene synthase. The role of the tricarboxylic acid moiety. Bioorg Med Chem Lett3:2541-2546 (1993) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene synthase |
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| Name: | Squalene synthase |
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| Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48109.41 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1336736 |
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| Residue: | 416 |
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| Sequence: | MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQA
LDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRV
VLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVG
IGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYV
KKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAK
QLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
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| BDBM50281076 |
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| n/a |
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| Name | BDBM50281076 |
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| Synonyms: | Squalestatin analog | {[(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trien-1-yl]phosphinato}formate |
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| Type | Small organic molecule |
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| Emp. Form. | C18H29O4P |
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| Mol. Mass. | 340.3953 |
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| SMILES | [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]-[#6](-[#6])=[#6]-[#6]-[#6]-[#6]P([#8-])(=O)[#6](-[#8-])=O |w:13.13| |
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| Structure | 
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