Reaction Details |
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Target | Squalene synthase |
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Ligand | BDBM50281082 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_202106 |
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IC50 | 177000±n/a nM |
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Citation | Watson, NS; Bell, R; Chan, C; Cox, B; Hutson, JL; Keeling, SE; Kirk, BE; Procopiou, PA; Steeples, IP; Widdowson, J The squalestatins: potent inhibitors of squalene synthase. The role of the tricarboxylic acid moiety. Bioorg Med Chem Lett3:2541-2546 (1993) Article |
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More Info.: | Get all data from this article, Assay Method |
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Squalene synthase |
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Name: | Squalene synthase |
Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase |
Type: | PROTEIN |
Mol. Mass.: | 48109.41 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1336736 |
Residue: | 416 |
Sequence: | MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQA
LDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRV
VLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVG
IGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYV
KKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAK
QLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
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BDBM50281082 |
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n/a |
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Name | BDBM50281082 |
Synonyms: | (Hydroxy-methoxy-phosphorylmethyl)-((3E,7E)-4,8,12-trimethyl-trideca-3,7,11-trienyl)-phosphinic acid anion | (Hydroxy-methoxy-phosphorylmethyl)-(4,8,12-trimethyl-trideca-3,7,11-trienyl)-phosphinic acid anion |
Type | Small organic molecule |
Emp. Form. | C18H32O5P2 |
Mol. Mass. | 390.3923 |
SMILES | [#6]-[#8]P([#8-])(=O)[#6]P([#8-])(=O)[#6]=[#6]-[#6]-[#6](-[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6] |w:10.10| |
Structure |
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