| Reaction Details |
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 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase type 2 |
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| Ligand | BDBM50366340 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_44 (CHEMBL615156) |
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| Ki | 250±n/a nM |
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| Citation |  Auger, S; Luu-The, V; Sam, KM; Poirier, D 3-Hydroxy-19-nor-17-pregna-1,3,5(10)-triene-21,17-carbolactone as inhibitor of 17-hydroxysteroid dehydrogenase type 2 Bioorg Med Chem Lett4:2045-2048 (1994) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 17-beta-hydroxysteroid dehydrogenase type 2 |
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| Name: | 17-beta-hydroxysteroid dehydrogenase type 2 |
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| Synonyms: | 17-beta-Hydroxysteroid Dehydrogenase 2 (17-beta-HSD2) | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB2_HUMAN | EDH17B2 | Estradiol 17-beta-dehydrogenase 2 | Estradiol 17-beta-dehydrogenase 2 (17beta-HSD2) | HSD17B2 | Microsomal 17-beta-hydroxysteroid dehydrogenas | SDR9C2 | Testosterone 17-beta-dehydrogenase |
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| Type: | Oxidoreductase; single-pass type II membrane protein |
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| Mol. Mass.: | 42795.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Enzyme was partially purified from human placenta. |
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| Residue: | 387 |
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| Sequence: | MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG
AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL
LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT
MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI
LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD
YFAKRHFGQDKPMPRALRMPNYKKKAT
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| BDBM50366340 |
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| n/a |
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| Name | BDBM50366340 |
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| Synonyms: | CHEMBL514046 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26O3 |
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| Mol. Mass. | 326.4293 |
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| SMILES | C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CC[C@@]21CCC(=O)O1 |
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| Structure | 
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