| Reaction Details |
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 | Report a problem with these data |
| Target | Neprilysin |
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| Ligand | BDBM50283653 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_144632 |
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| IC50 | 12±n/a nM |
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| Citation |  De Lombaert, S; Tan, J; Stamford, LJ; Sakane, Y; Berry, C; Ghai, RD Dual inhibition of neutral endopeptidase and angiotensin-converting enzyme by N-phosphonomethyl and N-carboxyalkyl dipeptides Bioorg Med Chem Lett4:2715-2720 (1994) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neprilysin |
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| Name: | Neprilysin |
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| Synonyms: | Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11 |
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| Type: | Enzyme |
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| Mol. Mass.: | 85505.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08473 |
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| Residue: | 750 |
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| Sequence: | MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
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| BDBM50283653 |
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| n/a |
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| Name | BDBM50283653 |
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| Synonyms: | 1-{(S)-3-Biphenyl-4-yl-2-[(S)-3-methyl-1-oxo-2-(phosphonomethyl-amino)-butylamino]-propionyl}-4-hydroxy-pyrrolidine-2-carboxylic acid | CHEMBL329372 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H34N3O8P |
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| Mol. Mass. | 547.5372 |
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| SMILES | CC(C)[C@H](NCP(O)(O)=O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1C[C@H](O)C[C@H]1C(O)=O |
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| Structure | 
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