| Reaction Details |
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 | Report a problem with these data |
| Target | Protein phosphatase 3 catalytic subunit alpha |
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| Ligand | BDBM50285470 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_42592 |
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| Kd | >1000±n/a nM |
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| Citation |  Teague, SJ; Cooper, ME; Stocks, MJ Synthesis of FK506-Cyclosporin hybrid macrocycles Bioorg Med Chem Lett5:2341-2346 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein phosphatase 3 catalytic subunit alpha |
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| Name: | Protein phosphatase 3 catalytic subunit alpha |
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| Synonyms: | CALNA | CNA | PP2BA_HUMAN | PPP3CA | Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | calcineurin |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58681.14 |
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| Organism: | Homo sapiens (Human) |
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| Description: | calcineurin 0 HUMAN::Q08209 |
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| Residue: | 521 |
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| Sequence: | MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESV
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV
DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD
AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG
NEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP
SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK
VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV
LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRIN
ERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ
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| BDBM50285470 |
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| n/a |
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| Name | BDBM50285470 |
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| Synonyms: | (9S,11R,19R,20R,23R)-3-Hydroxy-9-methoxy-11,14,19-trimethyl-6-oxo-15-propyl-20-(2-pyridin-3-yl-ethyl)-21-oxa-6lambda*4*-thia-1,14-diaza-bicyclo[21.3.1]heptacosane-2,13,16,22-tetraone | CHEMBL306125 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H59N3O8S |
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| Mol. Mass. | 705.945 |
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| SMILES | CCCC1N(C)C(=O)C[C@H](C)C[C@@H](CCS(=O)CCC(O)C(=O)N2CCC[C@H](C2)C(=O)O[C@H](CCc2cccnc2)[C@H](C)CCC1=O)OC |
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| Structure | 
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