| Reaction Details |
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 | Report a problem with these data |
| Target | Protein phosphatase 3 catalytic subunit alpha |
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| Ligand | BDBM50030448 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_42592 |
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| Kd | 20±n/a nM |
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| Citation |  Teague, SJ; Cooper, ME; Stocks, MJ Synthesis of FK506-Cyclosporin hybrid macrocycles Bioorg Med Chem Lett5:2341-2346 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein phosphatase 3 catalytic subunit alpha |
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| Name: | Protein phosphatase 3 catalytic subunit alpha |
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| Synonyms: | CALNA | CNA | PP2BA_HUMAN | PPP3CA | Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | calcineurin |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58681.14 |
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| Organism: | Homo sapiens (Human) |
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| Description: | calcineurin 0 HUMAN::Q08209 |
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| Residue: | 521 |
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| Sequence: | MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESV
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV
DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD
AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG
NEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP
SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK
VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV
LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRIN
ERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ
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| BDBM50030448 |
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| n/a |
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| Name | BDBM50030448 |
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| Synonyms: | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN | CHEMBL269732 | TACROLIMUS |
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| Type | Small organic molecule |
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| Emp. Form. | C44H69NO12 |
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| Mol. Mass. | 804.0182 |
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| SMILES | CO[C@@H]1C[C@@H](CC[C@H]1O)\C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@H](C[C@@H](C)C\C(C)=C\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC |r,t:45| |
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| Structure | 
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