Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 4

Ligand

BDBM50122871

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_3342

30±n/a nM

Citation

Langlois, M; Yang, D; Bremont, B; Shen, S Synthesis and pharmacological activity of a macrocyclic benzamide Bioorg Med Chem Lett5:795-798 (1995) Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 4

Name:

5-hydroxytryptamine receptor 4

Synonyms:

5-HT-4 | 5-HT4 | 5-HT4L | 5-HT4S | 5-hydroxytryptamine receptor 4 | 5HT4R_RAT | Htr4 | Serotonin (5-HT) receptor | Serotonin 4 (5-HT4) receptor

Type:

Enzyme Catalytic Domain

Mol. Mass.:

46117.31

Organism:

RAT

Description:

5-HT4 HTR4 RAT::Q62758

Residue:

406

Sequence:

MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSN
STFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRP
QTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRD
TVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS

BDBM50122871

n/a

Name

BDBM50122871

Synonyms:

7-Amino-6-chloro-10,13-dioxa-2,16-diaza-tricyclo[14.2.2.0*4,9*]icosa-4,6,8-trien-3-one | CHEMBL116913

Type

Small organic molecule

Emp. Form.

C16H22ClN3O3

Mol. Mass.

339.817

SMILES

Nc1cc2OCCOCCN3CCC(CC3)NC(=O)c2cc1Cl |(-1.23,-5.96,;.1,-5.19,;1.43,-5.96,;2.77,-5.19,;4.1,-5.96,;4.1,-7.49,;5.33,-8.36,;7.24,-7.78,;8.8,-8.71,;10.27,-7.82,;10.27,-5.68,;9.34,-4.92,;8.29,-2.86,;6.75,-2.86,;7.89,-3.75,;8.59,-5.56,;5.43,-3.63,;4.08,-2.87,;4.08,-1.33,;2.77,-3.64,;1.43,-2.87,;.1,-3.65,;-1.23,-2.88,)|

Structure