Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 4

Ligand

BDBM50083185

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_3320

440±n/a nM

Citation

Lopez-Rodriguez, ML; Morcillo, MJ; Benhamu, B; Riaguas, MD Novel benzimidazole-4-carboxylic acid derivatives as potent and selective 5-HT3 receptor ligands Bioorg Med Chem Lett6:1195-1198 (1996) Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 4

Name:

5-hydroxytryptamine receptor 4

Synonyms:

5-HT-4 | 5-HT4 | 5-HT4L | 5-HT4S | 5-hydroxytryptamine receptor 4 | 5HT4R_RAT | Htr4 | Serotonin (5-HT) receptor | Serotonin 4 (5-HT4) receptor

Type:

Enzyme Catalytic Domain

Mol. Mass.:

46117.31

Organism:

RAT

Description:

5-HT4 HTR4 RAT::Q62758

Residue:

406

Sequence:

MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSN
STFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRP
QTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRD
TVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS

BDBM50083185

n/a

Name

BDBM50083185

Synonyms:

6-Chloro-1H-benzoimidazole-4-carboxylic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester | CHEMBL416172

Type

Small organic molecule

Emp. Form.

C15H16ClN3O2

Mol. Mass.

305.759

SMILES

Clc1cc(C(=O)OC2CN3CCC2CC3)c2nc[nH]c2c1 |THB:6:7:13.14:11.10,(5.6,-10.41,;6.94,-11.18,;8.27,-10.41,;9.61,-11.2,;10.95,-10.44,;10.95,-8.9,;12.28,-11.21,;13.61,-10.44,;14.66,-11.44,;14.12,-9.66,;15.36,-8.29,;14.4,-7.28,;13.19,-8.62,;12.12,-8.41,;12.77,-9.39,;9.6,-12.74,;10.74,-13.77,;10.11,-15.19,;8.57,-15.03,;8.27,-13.51,;6.94,-12.72,)|

Structure