| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor receptor superfamily member 10A |
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| Ligand | BDBM50287632 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54694 (CHEMBL669549) |
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| IC50 | 80±n/a nM |
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| Citation |  Hanson, GJ; Vuletich, JL; Bedell, LJ; Bono, CP; Howard, SC; Welply, JK; Woulfe, SL; Zacheis, ML Design of MHC class II (DR4) ligands using conformationally restricted imino acids at p3 and p5 Bioorg Med Chem Lett6:1931-1936 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tumor necrosis factor receptor superfamily member 10A |
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| Name: | Tumor necrosis factor receptor superfamily member 10A |
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| Synonyms: | APO2 | CD_antigen=CD261 | DR4 | Death receptor 4 | TNF-related apoptosis-inducing ligand receptor 1 | TNFRSF10A | TR10A_HUMAN | TRAIL receptor 1 | TRAIL receptor-1 | TRAIL-R1 | TRAILR1 | Tumor necrosis factor receptor superfamily member 10A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50092.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_47861 |
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| Residue: | 468 |
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| Sequence: | MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMG
QHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGT
QQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPC
TTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNI
WVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGAEDNAHNEIL
SNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLVPANGADP
TETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLMKWVNKTG
RNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE
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| BDBM50287632 |
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| n/a |
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| Name | BDBM50287632 |
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| Synonyms: | CHEMBL1253325 | PKYVKQNTLKLAT (HA306-318 peptide) |
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| Type | Small organic molecule |
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| Emp. Form. | C69H118N18O19 |
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| Mol. Mass. | 1503.7844 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r| |
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| Structure | 
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