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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Prothrombin | ||
| Ligand | BDBM50289530 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_208316 | ||
| Ki | 2100±n/a nM | ||
| Citation |  Sanderson, PE; Dyer, DL; Naylor-Olsen, AM; Vacca, JP; Gardell, SJ; Dale Lewis, S; Lucas, BJ; Lyle, EA; Lynch, JJ; Mulichak, AM L-373,890, An achiral, noncovalent, subnanomolar thrombin inhibitor Bioorg Med Chem Lett7:1497-1500 (1997) Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Prothrombin | |||
| Name: | Prothrombin | ||
| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain | ||
| Type: | Protein | ||
| Mol. Mass.: | 70029.57 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P00734 | ||
| Residue: | 622 | ||
| Sequence: |
| ||
| BDBM50289530 | |||
| n/a | |||
| Name | BDBM50289530 | ||
| Synonyms: | CHEMBL3085115 | N-(4-Amino-cyclohexylmethyl)-2-[6-methyl-2-oxo-3-(toluene-4-sulfonylamino)-2H-pyridin-1-yl]-acetamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H30N4O4S | ||
| Mol. Mass. | 446.563 | ||
| SMILES | Cc1ccc(cc1)S(=O)(=O)Nc1ccc(C)n(CC(=O)NC[C@H]2CC[C@H](N)CC2)c1=O |wU:22.22,wD:25.26,(-7.05,-12.41,;-5.72,-11.62,;-5.72,-10.08,;-4.37,-9.31,;-3.04,-10.09,;-3.07,-11.62,;-4.37,-12.4,;-1.71,-9.31,;-.62,-8.22,;-2.8,-8.22,;-.38,-10.09,;.94,-9.31,;.94,-7.77,;2.27,-7,;3.63,-7.77,;4.95,-6.98,;3.63,-9.31,;4.95,-10.09,;4.95,-11.62,;6.28,-12.39,;3.63,-12.4,;4.02,-13.89,;5.5,-14.28,;6.59,-13.19,;8.07,-13.61,;8.46,-15.1,;9.95,-15.5,;7.37,-16.18,;5.89,-15.78,;2.27,-10.09,;2.27,-11.62,)| | ||
| Structure | 
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