Ki Summary

Reaction Details

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Target

Serine protease 1

Ligand

BDBM50289530

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_212727

2100±n/a nM

Citation

Sanderson, PE; Dyer, DL; Naylor-Olsen, AM; Vacca, JP; Gardell, SJ; Dale Lewis, S; Lucas, BJ; Lyle, EA; Lynch, JJ; Mulichak, AM L-373,890, An achiral, noncovalent, subnanomolar thrombin inhibitor Bioorg Med Chem Lett7:1497-1500 (1997) Article

More Info.:

Get all data from this article, Assay Method

Serine protease 1

Name:

Serine protease 1

Synonyms:

Type:

Enzyme

Mol. Mass.:

26557.80

Organism:

Homo sapiens (Human)

Description:

P07477

Residue:

247

Sequence:

MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS

BDBM50289530

n/a

Name

BDBM50289530

Synonyms:

CHEMBL3085115 | N-(4-Amino-cyclohexylmethyl)-2-[6-methyl-2-oxo-3-(toluene-4-sulfonylamino)-2H-pyridin-1-yl]-acetamide

Type

Small organic molecule

Emp. Form.

C22H30N4O4S

Mol. Mass.

446.563

SMILES

Cc1ccc(cc1)S(=O)(=O)Nc1ccc(C)n(CC(=O)NC[C@H]2CC[C@H](N)CC2)c1=O |wU:22.22,wD:25.26,(-7.05,-12.41,;-5.72,-11.62,;-5.72,-10.08,;-4.37,-9.31,;-3.04,-10.09,;-3.07,-11.62,;-4.37,-12.4,;-1.71,-9.31,;-.62,-8.22,;-2.8,-8.22,;-.38,-10.09,;.94,-9.31,;.94,-7.77,;2.27,-7,;3.63,-7.77,;4.95,-6.98,;3.63,-9.31,;4.95,-10.09,;4.95,-11.62,;6.28,-12.39,;3.63,-12.4,;4.02,-13.89,;5.5,-14.28,;6.59,-13.19,;8.07,-13.61,;8.46,-15.1,;9.95,-15.5,;7.37,-16.18,;5.89,-15.78,;2.27,-10.09,;2.27,-11.62,)|

Structure