Ki Summary

Reaction Details

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Target

D(2) dopamine receptor

Ligand

BDBM50290220

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_58455 (CHEMBL671651)

4.5±n/a nM

Citation

Belliotti, TR; Kesten, SR; Rubin, JR; Wustrow, DJ; Georgic, LM; Zoski, KT; Akunne, HC; Wise, LD Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands Bioorg Med Chem Lett7:2403-2408 (1997) Article

More Info.:

Get all data from this article, Assay Method

D(2) dopamine receptor

Name:

D(2) dopamine receptor

Synonyms:

Type:

Cell-surface receptors

Mol. Mass.:

50647.10

Organism:

Homo sapiens (Human)

Description:

P14416

Residue:

443

Sequence:

MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC

BDBM50290220

n/a

Name

BDBM50290220

Synonyms:

CHEMBL430439 | N-(4-{2-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-ethyl}-cyclohexyl)-benzamide

Type

Small organic molecule

Emp. Form.

C25H31Cl2N3O

Mol. Mass.

460.439

SMILES

Clc1cccc(N2CCN(CC[C@H]3CC[C@@H](CC3)NC(=O)c3ccccc3)CC2)c1Cl |wU:12.11,wD:15.18,(18.02,-6.23,;17.27,-7.58,;18.09,-8.9,;17.34,-10.25,;15.8,-10.29,;15.01,-8.97,;13.47,-8.99,;12.74,-10.34,;11.2,-10.37,;10.39,-9.06,;8.85,-9.08,;8.1,-10.43,;6.56,-10.44,;5.77,-11.77,;4.23,-11.77,;3.48,-10.44,;4.23,-9.11,;5.77,-9.11,;1.94,-10.45,;1.17,-11.78,;-.37,-11.79,;1.94,-13.11,;3.45,-13.1,;4.21,-14.42,;3.46,-15.76,;1.92,-15.76,;1.17,-14.43,;11.14,-7.71,;12.68,-7.68,;15.75,-7.61,;14.94,-6.31,)|

Structure