Ki Summary

Reaction Details

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Target

D(2) dopamine receptor

Ligand

BDBM50290211

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_58455

17±n/a nM

Citation

Belliotti, TR; Kesten, SR; Rubin, JR; Wustrow, DJ; Georgic, LM; Zoski, KT; Akunne, HC; Wise, LD Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands Bioorg Med Chem Lett7:2403-2408 (1997) Article

More Info.:

Get all data from this article, Assay Method

D(2) dopamine receptor

Name:

D(2) dopamine receptor

Synonyms:

Type:

Cell-surface receptors

Mol. Mass.:

50647.10

Organism:

Homo sapiens (Human)

Description:

P14416

Residue:

443

Sequence:

MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC

BDBM50290211

n/a

Name

BDBM50290211

Synonyms:

CHEMBL311575 | Thiophene-2-carboxylic acid {4-[2-(4-p-tolyl-piperazin-1-yl)-ethyl]-cyclohexyl}-amide

Type

Small organic molecule

Emp. Form.

C24H33N3OS

Mol. Mass.

411.603

SMILES

Cc1ccc(cc1)N1CCN(CC[C@H]2CC[C@@H](CC2)NC(=O)c2cccs2)CC1 |wU:13.13,wD:16.20,(19.33,-5.48,;17.79,-5.51,;17.04,-6.87,;15.5,-6.89,;14.71,-5.58,;15.45,-4.23,;16.97,-4.18,;13.17,-5.61,;12.37,-4.29,;10.83,-4.32,;10.09,-5.67,;8.55,-5.7,;7.79,-7.03,;6.25,-7.05,;5.47,-8.38,;3.93,-8.38,;3.17,-7.05,;3.93,-5.72,;5.47,-5.72,;1.63,-7.05,;.86,-8.38,;-.68,-8.4,;1.63,-9.71,;3.16,-9.81,;3.02,-12.46,;1.48,-12.37,;.78,-11.01,;10.9,-6.98,;12.44,-6.94,)|

Structure