Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM50290229

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_58772

4.3±n/a nM

Citation

Belliotti, TR; Kesten, SR; Rubin, JR; Wustrow, DJ; Georgic, LM; Zoski, KT; Akunne, HC; Wise, LD Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands Bioorg Med Chem Lett7:2403-2408 (1997) Article

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

Type:

n/a

Mol. Mass.:

44243.43

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

400

Sequence:

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM50290229

n/a

Name

BDBM50290229

Synonyms:

CHEMBL78406 | PD-137557 | Thiophene-2-carboxylic acid {4-[2-(4-pyridin-2-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-amide

Type

Small organic molecule

Emp. Form.

C22H30N4OS

Mol. Mass.

398.565

SMILES

O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2ccccn2)CC1)c1cccs1 |wU:3.2,wD:6.6,(5.88,-2.66,;5.57,-4.16,;6.69,-5.2,;8.16,-4.71,;8.48,-3.22,;9.95,-2.75,;11.09,-3.78,;12.56,-3.32,;13.68,-4.36,;15.15,-3.88,;16.29,-4.92,;17.74,-4.46,;18.08,-2.96,;16.95,-1.92,;15.48,-2.38,;19.55,-2.49,;20.67,-3.53,;22.14,-3.08,;22.47,-1.57,;21.33,-.52,;19.87,-.99,;10.76,-5.29,;9.3,-5.75,;4.09,-4.64,;3.62,-6.1,;2.08,-6.1,;1.62,-4.64,;2.85,-3.74,)|

Structure