| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50070545 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_142731 |
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| IC50 | 710±n/a nM |
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| Citation |  Kubota, H; Okamoto, Y; Fujii, M; Ikeda, K; Takeuchi, M; Shibanuma, T; Isomura, Y Synthesis and NK1 receptor antagonistic activity of (+/-)-1-acyl-3-(3,4- dichlorophenyl)-3-[2-(spiro-substituted piperidin-1'-yl)ethyl]piperidines. Bioorg Med Chem Lett8:1541-6 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK1R_CAVPO | Neurokinin 1 receptor | Neurokinin NK1 | TAC1R | TACR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 46261.42 |
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| Organism: | GUINEA PIG |
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| Description: | Neurokinin NK1 TACR1 GUINEA PIG::P30547 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVC
MIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTIST
VVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS
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| BDBM50070545 |
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| n/a |
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| Name | BDBM50070545 |
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| Synonyms: | 1'-[3-(3,4-dichlorophenyl)-4-methyl(phenyl)carboxamidobutyl]spiro[1,3-dihydroisobenzofuran-1,4'-(hexahydropyridine)] | CHEMBL39049 | YM-35375 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H32Cl2N2O2 |
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| Mol. Mass. | 523.493 |
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| SMILES | CN(CC(CCN1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 |
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| Structure | 
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