| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1B adrenergic receptor |
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| Ligand | BDBM50071689 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_33013 |
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| Ki | 2200±n/a nM |
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| Citation |  Patane, MA; DiPardo, RM; Price, RP; Chang, RS; Ransom, RW; O'Malley, SS; Di Salvo, J; Bock, MG Selective alpha-1a adrenergic receptor antagonists. Effects of pharmacophore regio- and stereochemistry on potency and selectivity. Bioorg Med Chem Lett8:2495-500 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1B adrenergic receptor |
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| Name: | Alpha-1B adrenergic receptor |
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| Synonyms: | ADA1B_HUMAN | ADRA1B | Adrenergic alpha1B | Adrenergic receptor | Adrenergic receptor alpha | Alpha 1B-adrenoceptor | Alpha 1B-adrenoreceptor | Alpha-1B adrenergic receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 56862.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35368 |
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| Residue: | 520 |
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| Sequence: | MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFV
RILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRT
LPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLT
EPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
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| BDBM50071689 |
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| n/a |
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| Name | BDBM50071689 |
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| Synonyms: | 1-[4-(5-Chloro-1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-yl)-butyl]-4-phenyl-piperidine-4-carboxylic acid methyl ester | CHEMBL79532 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27ClN2O5S |
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| Mol. Mass. | 491 |
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| SMILES | COC(=O)C1(CCN(CCCCN2C(=O)c3cc(Cl)ccc3S2(=O)=O)CC1)c1ccccc1 |
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| Structure | 
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