| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
|---|
| Ligand | BDBM50005560 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_62480 (CHEMBL677372) |
|---|
| Ki | 10400±n/a nM |
|---|
| Citation |  Kozikowski, AP; Simoni, D; Roberti, M; Rondanin, R; Wang, S; Du, P; Johnson, KM Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity. Bioorg Med Chem Lett9:1831-6 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent dopamine transporter |
|---|
| Name: | Sodium-dependent dopamine transporter |
|---|
| Synonyms: | DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 68749.45 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | P23977 |
|---|
| Residue: | 619 |
|---|
| Sequence: | MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDH
QLVDRGEVRQFTLRHWLLL
|
|
|
|---|
| BDBM50005560 |
|---|
| n/a |
|---|
| Name | BDBM50005560 |
|---|
| Synonyms: | 3-Benzoyloxy-8-methyl-8-azonia-bicyclo[3.2.1]octane | Benzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester | Benzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester (tropine benzoate) | PSEUDOCOCAINE | R-Benzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H19NO4 |
|---|
| Mol. Mass. | 289.3264 |
|---|
| SMILES | COC(=O)[C@H]1C2CCC(C[C@@H]1OC(=O)c1ccccc1)N2 |r,TLB:11:10:6.7:20,THB:2:4:6.7:20| |
|---|
| Structure | 
|
|---|
Search and Browse
