| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M3 |
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| Ligand | BDBM50079583 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_138244 (CHEMBL745494) |
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| Ki | 5.9±n/a nM |
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| Citation |  Sabb, AL; Husbands, GM; Tokolics, J; Stein, RP; Tasse, RP; Boast, CA; Moyer, JA; Abou-Gharbia, M Discovery of a highly potent, functionally-selective muscarinic M1 agonist, WAY-132983 using rational drug design and receptor modelling. Bioorg Med Chem Lett9:1895-900 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M3 |
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| Name: | Muscarinic acetylcholine receptor M3 |
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| Synonyms: | ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 66151.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P20309 |
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| Residue: | 590 |
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| Sequence: | MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
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| BDBM50079583 |
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| n/a |
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| Name | BDBM50079583 |
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| Synonyms: | (R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane; hydrochloride | CHEMBL542622 | WAY-132983 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H25N3OS |
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| Mol. Mass. | 307.454 |
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| SMILES | CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2 |TLB:13:14:20:18.17| |
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| Structure | 
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