| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M2 |
|---|
| Ligand | BDBM50079583 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_140091 (CHEMBL752968) |
|---|
| Ki | 3.4±n/a nM |
|---|
| Citation |  Sabb, AL; Husbands, GM; Tokolics, J; Stein, RP; Tasse, RP; Boast, CA; Moyer, JA; Abou-Gharbia, M Discovery of a highly potent, functionally-selective muscarinic M1 agonist, WAY-132983 using rational drug design and receptor modelling. Bioorg Med Chem Lett9:1895-900 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Muscarinic acetylcholine receptor M2 |
|---|
| Name: | Muscarinic acetylcholine receptor M2 |
|---|
| Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 |
|---|
| Type: | GPCR |
|---|
| Mol. Mass.: | 51730.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08172 |
|---|
| Residue: | 466 |
|---|
| Sequence: | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
|
|
|
|---|
| BDBM50079583 |
|---|
| n/a |
|---|
| Name | BDBM50079583 |
|---|
| Synonyms: | (R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane; hydrochloride | CHEMBL542622 | WAY-132983 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H25N3OS |
|---|
| Mol. Mass. | 307.454 |
|---|
| SMILES | CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2 |TLB:13:14:20:18.17| |
|---|
| Structure | 
|
|---|
Search and Browse
