| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50076948 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_48974 |
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| IC50 | 2900±n/a nM |
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| Citation |  Adang, AE; Peters, AM; Gerritsma, S; de Zwart, E; Veeneman, G Solution-phase and solid-phase synthesis of novel transition state inhibitors of coagulation enzymes incorporating a piperidinyl moiety. Bioorg Med Chem Lett9:1227-32 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50076948 |
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| n/a |
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| Name | BDBM50076948 |
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| Synonyms: | (R)-1-((3R,4R,4aR)-Decahydro-isoquinoline-1-carbonyl)-pyrrolidine-2-carboxylic acid ((S)-2-benzylcarbamoyl-2-oxo-1-piperidin-4-ylmethyl-ethyl)-amide | CHEMBL20614 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H45N5O4 |
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| Mol. Mass. | 551.7201 |
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| SMILES | O=C(N[C@@H](CC1CCNCC1)C(=O)C(=O)NCc1ccccc1)[C@H]1CCCN1C(=O)[C@@H]1NCC[C@H]2CCCC[C@@H]12 |
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| Structure | 
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